Cross-Reactivity

Instant CLIA Waived devices (Point of Care Devices) can trigger false (positive or negative) results. All manufacturers encourage or mandate any positive test must be sent to Mass Spec for further interpretation. Medical Distribution Group, Inc. offers confirmation services. Please call 727-744-2967 for more information.

If the device has triggered a disputed positive result please use this page as a list of possible cross reactions. Please note this list is not 100% conclusive and may not include all known cross reactive drugs. Always reference the CLIA insert included with every box purchased from Medical Distribution Group, Inc.

Amphetamines (AMP)

Adderall
Adderall XR
Amantadine
Benzphetamine
Bupropion
Chlorpromazine
/-Deprenylc
Desipramine
Dextroamphetamine Sulfate
Dexedrine
Ephedrine
Fenproporexb
Fluoxetine (Prozac)
Isometheptene
Isoxsuprine
Labetalol
MDMA
Methamphetamine (Vick's Inhaler)
Methylenedioxyamphetamine (MDA)
Methylphenidate
Phentermine
Phenylephrine
Phenylpropanolamine
Promethazine
Pseudoephedrine
Ranitidine
Ritodrine
Selegiline
Thioridazine
Trazodone
trimethobenzamide
Trimipramine
Vyvanse (c)
Adderall, Adderall XR, Dexedrine Dextroamphetamine)

Common Over the Counter Drugs that trigger Positive results for AMP: Afrinol, Vicks Vapor Inhaler, Sudafed, Tylenol Cold, Pseudoephedrine

Slang for AMP- Eve, Love Drug, Speed, Uppers

Benzodiazepines (BZO/ BZD)

Etizolam
Melatonin (Sleep Aid)
Oxaprozin (Daypro) NSAIDs
Bromopheniramine (Lexotan)
Sertraline
Xanex (Alprozolam)
Lexotan (Bromazepam)
Librium (Clordiazepoxide)
Frisium (Clobazam)
Clonopin, Klonopin, Rivotril(Clonazepam)
Tranxene (Clobazam)
Librium (Clorazepate)
Briantum (Delorazepam)
Diazemuls, Stesolid, Valclair, Valium (Diazepam)
ProSom (Estazolam)
Rohypnol (Estazolam)
Rohypnol, Prosom (Fluntirazepam),
Alapryl, Paxipan, Pacinone (Halazepam)
Lofepramide, Ativan (Lorazepam)
Noctamide (Lormetazepam)
Anxitol, Lerisum, Medacepan, Nobritol, Nobrium (Medazepam)
Mogadon, Somnite (Nitrazepam)
Serax, Ox-pam (Oxazepam)
Centrax, Demtrin (Prazepam)
Zoloft (Sertraline)
Restoril (Temazepam)
Halcion (Triazolam)

Barbiturates (BAR)

Allobarbital
Alphenol
Amytal, Tuinal
Aprobarbital (Amytal, Tuinal)
Barbital
Butisol, Soneryl (Butabarbital)
Fioricet, Fiorinal (Butalbital)
Ibuprofen
Nembutal (Pentobarbitone)
Galenphol, Strong BP, Pavacol-D
Thebacon (Phenobarbitone)
Seconal (Secobarbital)
Phenytoin (Dilantin, Epanutin, Epitard) - Cross Reaction

Cannabinoids (THC)

Dronabinol
Efavirenz
Hemp-containing Foods
NSAIDs
Proton Pump Inhibitors
Tolmetin
Sustiva (Efavirenz)

Cocaine

Coca leaf Tea
Topical Anesthetics containing cocaine
Heavy exposure to cocaine smoke.
Efavirenz (Sustiva)

Fentanyl

Vistaril (Ataraxic)
Buspirone

Methadone (MTD)

Diphenhydramine (Benadryl) Cross Reaction
Verapamil Metabolites
Dolophine
Methadose
Physetone (Methadone Hydrochloride)

Methamphetamine (MAMP/ M-AMP)

Desoxyn
Methedrine
Methamprex (d-Methamphetamine HCL)
Vick's Inhaler (I-Methampetamine HCL)
Combination: Afrinol, Sudafed & Tylenol Cold (Pseudoephedrine)
Pylorid
Zantac (Ranitidine)
Methylenedioxymethamphetamine (MDMA)

Opiods/ Opiates/ Heroin (OPI, MOR/MOP)

Dextromethorphan
Heroin8
Diphenhydraminee
Dihydrocofeine (Paramol, Remedeine, Remedeine Forte)
Heroin
Codeine
Hydromorphone
Hydrocodone
Morphine
Poppy Seeds (In high dosage)
Quinine
Quinolones
Rifampin
DHC Continus, Paramol, Remedeine, (Digydrcodeine)
Tylenol 3, Tylenol with codeine
Paracetamol with Codeine
Codafen Continus
Codeine Linctus
Strong BP (Pholcodine)
Pavacol-D (Pholcodine)
Galcodine
Kapake
Migraleve
Novocain (Procaine)
Solpadol
Tylex (Codeine Phosphate)
Ethylmorphine
Lorcet
Lortabe
Vicodin (Hydrocodone)
Diocalm, Emtersam. Opazimes (Koalin and Morphine Mixture)
Dilaudid
Locoid C
Entersan
Opazimes (Koalin and Morphone Mixture)
Astramorph (Morphine)
Cyclimorph (Morphine)
Duramorph (Morphine)
Morcap (Morphine)
Morphone Sulfate (Morphine)
MS Contin (Morphine)
Oramorph (Morphine)
Roxanol (Morphine)
Severedol(Morphine)

Oxycodone (OXY)

Oxycontin
Percodan
Roxicet (Oxycodone)
Dilaudid, Hydrostat (Hydrocodone)
Lorcet, Loratab, Vicodin (Hydrocodone)

Phencyclidine (PCP)

Dextromethorphan
Diphenhydraminee
Doxylamine
Ibuprofen
Imipramine
Ketamine
Meperidine
Mesoridazine
Thioridazine
Tramodol
Venlafaxine
O-desmethylvenlafaxine
Lamitcal (Lamotrigine)
Venlafaxine (Effexor, Effexor XL)

Tricyclic Antidepressants (TCA)

Carbamazepinef
Cyclobenzaprine
Cyprobenzaprine
Diphenhydramine
Flexeril
Periactin
Hydroxyzine
Quetiapine
Elavil (Amitripthyline)
Lentizol
Tryptizol
Triptafen
Sinequan
Xepin (Doxepin)
Gamanil
Lomont (Lofepramine)
Promithazine (Allerfen, Anergan, Antiaus, Aprobit, Avomine, Baymethzine, Diprozin, Fenergan, Methazine, Phenergen)
Dothiepin (Prothiaden)

Tricyclic Antidepressants (TCA) False Positive Information

Although assays for drugs of abuse do not routinely test for TCAs, rapid screening for TCA in the urine is often valuable in emergency situations, such as intentional over dose or toxicity. Results of urine screening for TCA have an important role in determining early management of patients; however, many commonly prescribed and over-the counter medications can lead to false-positive results from TCA assays. The 3-ring nucleus of TCAs is the characteristic structure of this class of antidepressants. Several structurally related medications (ie, 3-ringed structures) have been shown to cross-react with TCAs in either serum or urine immunoassays. Antihistamine agents (eg, cyproheptadine, carbamazepine, cyclobenzaprine, and quetiapine) have often been reported to interfere with the serum immunoassay for TCAs because of their 3-ringed structures. Although structurally dissimilar to TCAs, the antihistamines diphenhydramine, hydroxyzine, and cetirizine (hydroxyzine’s metabolite) have also been shown to interfere with TCA immunoassay in overdose situations. Unfortunately, these case reports did not test for interference in the urine immunoassay, except for quetiapine and cyclobenzaprine.